11111 111 0000 0001 110 1111 1111 25510 0000 0000 0010
The carry bit of 1 out of the high order column (leftmost) indicates an overflow.
Unsigned binary representation can not be used to represent negative integers. With paper and pencil numbers, a number is made negative by putting a negative sign in front of it: 2410 negated = -2410. You might hope to do the same with binary integers:
0001 1000 negated = -0001 1000 ???
Unfortunately, you can't put a negative sign in front of a bit pattern in computer memory. Memory holds only patterns of 0's and 1's. Somehow negative integers must be represented using bit patterns. But this is certainly possible. Remember those advantages of binary?
If we can represent negative integers with paper and pencil (thus using symbols) we certainly can represent negative integers with patterns of bits.
Let us say that you need to represent an equal number of positive and negative integers in eight bits. How many negative numbers can represented? How many positive numbers?
Just for fun, can you think of a way to do this? Get out some scratch paper and scratch for a while with eight-bit patterns.